Antigen Presentation, Recognition and the Immune Response

Antigen-driven patterns of TCR bias are shared across diverse outcomes of human hepatitis C virus infection

JJ Miles, D Thammanichanond, S Moneer, UK Nivarthi, L Kjer-Nielsen, SL Tracy, CK Aitken, RM Brennan, W Zeng, L Marquart, D Jackson, SR Burrows, DS Bowden, J Torresi, M Hellard, J Rossjohn, J McCluskey, M Bharadwaj

2011-01-15

Hepatitis C virus (HCV) infection causes significant morbidity and mortality worldwide. T cells play a central role in HCV clearan..

TCD8 response in diverse outcomes of recurrent exposure to hepatitis C virus

M Bharadwaj, D Thammanichanond, CK Aitken, S Moneer, HE Drummer, S Tracy, R Holdsworth, S Bowden, D Jackson, M Hellard, J Torresi, J McCluskey

2009-08-01

To analyse the immune correlates in a setting of recurrent exposure to hepatitis C virus (HCV), we studied T<inf>CD8</inf> respons..

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

RS Allan, J Waithman, S Bedoui, CM Jones, JA Villadangos, Y Zhan, AM Lew, K Shortman, WR Heath, FR Carbone

2006-07-01

Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here we show that after skin infection w..

Latent infection with herpes simplex virus is associated with ongoing CD8 T-cell stimulation by parenchymal cells within sensory ganglia

AL Van Lint, L Kleinert, SRM Clarke, A Stock, WR Heath, FR Carbone

2005-12-01

CD8⁺ T-cell persistence can be seen in ganglia harboring latent herpes simplex virus (HSV) infection. While there is so..

SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

GM Davey, R Starr, AL Cornish, JT Burghardt, WS Alexander, FR Carbone, CD Surh, WR Heath

2005-10-17

Mice that are deficient in suppressor of cytokine signaling-1 (SOCS-1) succumb to neonatal mortality that is associated with exten..